Chemical Toxicity, Mechanism of Action, Biomarker Discovery for Risk Assessment, and Bioremediation of
(Rapid Detonation Explosive
--- Royal Demolition
- The field of chemical toxicology applies biology, chemistry, and medicine concerned with the study of the
adverse effects of chemicals on
living organisms. It is the study of symptoms, mechanisms, treatments and detection of
poisoning, especially the poisoning of animals and people.
- RDX (C3H6N606,
Cyclotrimethylenetrinitramine), an initialism for
Research Department Explosive (It is also known as
cyclonite or hexogen), is an explosive
nitroamine widely used in military and
industrial applications. RDX is at 16th of the 1,397 hazardous
waste chemicals on the EPA National Priorities
List. U.S. Army has identified 583 confirmed and 88 suspicious RDX contaminated sites.
RDX is also on the EPA's
Drinking Water Contaminant Candidate List (CCL) and
Emerging Contaminant List.
- The toxicity of RDX has been well documented to many
living organisms. This program is airming at identifying its Mechanism of
Action such as the specific molecular targets to which the RDX interacts with, such as an enzyme
or receptor or pathway.
- We are also interested in locating biomarkers
(a set of genes responsive to RDX perturbation) via various omics-based
technologies such as transcriptomics, metablomics, and proteomics. These biomakers can be used as an indicator of a
particular disease state or some other physiological state
of an organism due to exposures to the contamination of RDX.
- We will build a knowledgebase
system, to be used as "Google" for environmental scientists and decision makers, ---- a complex
database system with search engine that allows ecotoxicologists to read, understand, synthesize,
and find solutions to solve the problems of munitions contamination on reported sites.
- Our final goal is to design biosensors to
detect RDX contamination in battle fields, military installations, firing and training ranges
for our force health protection,
surveillance for people dealing with munitions, and also to discover
approaches for the cleanup of the RDX contaminated sites to safe gurad military munitions
manufacture and installtion, and the
health of army firing and training ranges.