Selected Latest Publications on RDX Toxicity, Mode of Action and
Biomaker Discovery via Systems Biology Approach




  1. Gust et al. 2009: Neurootoxicogenomic Investigations to Assess Mechanisms of Action of the Munitions Constituents RDX and 2,6-DNT in Northern Bobwhite (Colinus virginianus). Toxicological Sciences (impact factor 4.8), 110(1), 168-180.
  2. Gust et al. 2011: Genomic investigation of year long and multi-generational exposures of fathead minnow to the munitions compound RDX. Environmental Toxicology and Chemistry (impact factor 2.7).
  3. Garcia-Reyero et al. 2011: Conserved toxic responses across divergent phylogenetic lineages: a meta-analysis of the neurotoxic effects of RDX among multiple species using toxicogenomics. Ecotoxicology (impact factor 3.5), 20(3): 580-594(15).
  4. Li. et al. 2010. Identification and Optimization of Classifier Genes from Multi-Class Earthworm Microarray Dataset. PlosOne (impact factor 4.3), 5(10):e13715.
  5. Gust et al. 2011: Investigations of transcript expression in fathead minnow (Pimephales promelas) brain tissue reveal toxicological impacts of RDX exposure. Aquatic Toxicology (impact factor 3.8), 101: 135-145.
  6. RDX induces aberrant expression of microRNAs in mouse brain and liver. Environmental Health Perspectives (impact factor 6.2), 117: 231-240.
  7. Gong et al. 2008: Transcriptomic analysis of RDX and TNT interactive sublethal effects in the earthworm Eisenia fetida. BMC Genomics, 9(Suppl 1):S15.
  8. Gust et al. 2011: Investigations of transcript expression in fathead minnow (Pimephales promelas) brain tissue reveal toxicological impacts of RDX exposure. Aquatic Toxicology, 101:(1): 135-145.
  9. Bannon et al. 2009: Global Gene Expression in Rat Brain and Liver after Oral Exposure to the Explosive Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). Chemical Research in Toxicology (impact factor 3.4), 22(4): 620-625.
  10. Garcia-Reyero et al. 2009: Biomarker Discovery and Transcriptomic Responses in Daphnia magna exposed to Munitions Constituents. Environmental Science & Technology (impact factor 4.3), 43(11): 41-4193.
  11. Perkins et al. 2006: Comparison of transcriptional responses in liver tissue and primary hepatocyte cell cultures after exposure to hexahydro-1, 3, 5-trinitro-1, 3, 5-triazine. BMC Bioinformatics, 7(Suppl 4):S22.
  12. Lotufo et al. 2010: Toxicity and bioconcentration evaluation of RDX and HMX using sheepshead minnows in water exposures. Ecotoxicology and Environmental Safety, 73(7) : 1653-1657


Useful Literature



First set up on May 13, 2011, last updated by Dr. Jeff Chen on July 1, 2011.