|Gene Number||Gene Symbol and Name||Low Dose||High Dose||Possible Relavent Function||More Information on Role or Phenotype||1||Scd1,
(Stearoyl-Coenzyme A desaturase 1)
|Up||Down||Essential for epidermal integrity and Notch-mediated signaling.|
(MARVEL domain containing 1)
||No known phenotype yet in human,
but down-regulated in primary multiple tumors derived from ovary, vulva, uterus, cervix, breast,
testis, kidney bladder and liver.
Check NCBI on MARVEL1
(iron-binding nuclear protein).
|Down||Down||Pirin functions as a co-factor for NFI/CTF1 and Bcl-3, implicating it in DNA
replication, transcriptional activation, and apoptosis.
Check GeneCards for Detail
(ubiquitin specific peptidase 2).
|Up||Up||Involved in the regulation of intracellular protein breakdown, cell cycle
regulation, and stress response.
USP2 in wikigenes.
(hepcidin antimicrobial peptide).
The HAMP gene provides instructions for the production of a protein called hepcidin, hepcidin plays a
major role in maintaining iron balance in the body.
(P450 (cytochrome) oxidoreductase).
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The electron donor protein
for several oxygenase enzymes found on the endoplasmic reticulum of most eukaryotic cells.
NCBI GeneReview on Por
(aldehyde dehydrogenase family 1, subfamily A1).
Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two
major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their
electrophoretic mobilities, kinetic properties, and subcellular localizations.
|8||Polg2 polymerase (DNA directed),gamma 2, accessory subunit.||Up||Up||
This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded
protein forms a heterotrimer containing one catalytic subunit and two processivity subunits.
(coenzyme Q-binding protein).
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Most coenzyme Q (CoQ) exists freely in the mitochondrial membrane as a CoQ pool. Required for
function of coenzyme Q in the respiratory chain.
Coq10b in Wiki Gene
(major facilitator superfamily domain containing 2).
The encoded protein likely
functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin
NCBI Human Mfsd2.
(ER degradation enhancer, mannosidase alpha-like 1).
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are
retained in the cell
through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of
accelerate degradation of misfolded glycoproteins in the ER.
Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality.
(cytochrome P450, family 2, subfamily b, polypeptide 1).
We like this gene !
|Up||Up||Cyp2b1 oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|
(acyl-CoA synthetase medium-chain family member 2).
Constitutes the rate-determining step in the pathway for the conjugation of most xenobiotics and
therefore plays a role in detoxification, and is important for the intermediary metabolism of short-
and medium-chain fatty acids.
(solute carrier family 38, member 2).
|Up||Up||Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.|
Sds is the serine dehydratase structural gene. Albino region deletions profoundly affect development
and expression of some gluconeogenic enzymes, including Sds. In these deletion mice, Sds is expressed
normally on the constitutive level, but fails to develop hormone-inducible expression.
Sds in iHOP
This enzyme helps break down the amino acid tyrosine, a protein building block found in many foods.
Tyrosine aminotransferase is the first in a series of five enzymes that converts tyrosine to smaller
molecules, which are excreted by the kidneys or used in reactions that produce energy.
Tyrosine aminotransferase Wiki.
(zinc finger protein 354A).
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Amino acid sequence contains Kruppel-associated box (KRAB) A and B domains in the N terminus and
Kruppel-type zinc finger motifs in the C terminus.
Zfp354a in WikiGenes.
Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently
leads to their degradation by the 26S proteasome.
Ubd in WikiGenes
(aldehyde dehydrogenase family 1, subfamily A7).
Protein type: Oxidoreductase
Cellular Component: cytoplasm
Molecular Function: identical protein binding; aldehyde dehydrogenase (NAD) activity; 3-chloroallyl aldehyde dehydrogenase activity; benzaldehyde dehydrogenase (NAD+) activity; oxidoreductase activity
Biological Process: metabolic process; retinoic acid metabolic process; protein homotetramerization
Alt. Names/Synonyms: Ahd2-like; AI987940; AL1A7; Aldehyde dehydrogenase 1 (phenobarbitol inducible); Aldehyde dehydrogenase family 1 member A7; aldehyde dehydrogenase family 1, subfamily A4; aldehyde dehydrogenase family 1, subfamily A7; Aldehyde dehydrogenase phenobarbital-inducible; Aldehyde dehydrogenase, cytosolic 1; ALDH class 1; ALDH-E1; Aldh-pb; Aldh1a4; Aldh1a7; Aldhpb; ALHDII
Gene Symbols: Aldh1a7
Molecular weight: 54,588 Da.
Aldh1a7 in NCBI AceView
Nr0b2 (transcription factor),
(nuclear receptor subfamily 0, group B, member 2).
Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits
transactivation of the nuclear receptor with whom it interacts.
NR0B2 is an orphan nuclear receptor.
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(insulin-like growth factor binding protein 1).
|Up||Up||The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.|
|Up||Up||Tsukushi (TSK), a member of the secreted small leucine rich repeat proteoglycan family, functions as a key coordinator of multiple pathways outside of cells through the regulation of an extracellular signaling network.|
(flavin containing monooxygenase 5).
||Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs,pesticides, and xenobiotics.|
|24||LOC683460, (hypothetical protein).||Up||Up||N/A||N/A|
|25||LOC684871, (similar to Protein C8orf4 (Thyroid cancer protein 1) (TC-1)).||Up||Up||N/A||N/A|
(1) Genes with expression of at least 2 fold changes with confidence P-value < 0.05 are selected for further data mining.
(2) Three probe sets with no known annotation (13781811_at, 1372524_at, and 1380306_at) are also up regulated as well in RDX perturbation.