• RDX primarily down-regulated neurotransmission in brain -- the target organ of toxicity.

  • The affected metabolisms were up-regulatored in liver -- the site of metabolism.

  • In summary, oral dose of RDX is quickly absorbed and transported into the brain where processes related neurotransmission are negatively affacted, consistent with a potential excitoxic response, whereas in liver there was a postive effect on biological process potentially associted with RDX metabolism.

Useful Internet Links on Analyzed Tissues

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First setup on May 06, 2011, last updated by Dr. Jeff Chen on May 16, 2011.