- RDX primarily down-regulated
brain -- the target
organ of toxicity.
- The affected metabolisms were up-regulatored in
liver -- the site of metabolism.
- In summary, oral dose of RDX is quickly absorbed and
transported into the brain where processes related neurotransmission are negatively affacted,
consistent with a potential excitoxic response,
whereas in liver there was a postive effect on biological process potentially associted with RDX metabolism.