• RDX primarily down-regulated neurotransmission in brain -- the target organ of toxicity.

  • The affected metabolisms were up-regulatored in liver -- the site of metabolism.

  • In summary, oral dose of RDX is quickly absorbed and transported into the brain where processes related neurotransmission are negatively affacted, consistent with a potential excitoxic response, whereas in liver there was a postive effect on biological process potentially associted with RDX metabolism.


Useful Internet Links on Analyzed Tissues

Possible Mode of Action








First setup on May 06, 2011, last updated by Dr. Jeff Chen on May 16, 2011.